解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-155
更新日期:2014-08-31 00:00:00
abstract:BACKGROUND:The deciphering of cellular networks to determine susceptibility to infection by HIV or the related simian immunodeficiency virus (SIV) is a major challenge in infection biology. RESULTS:Here, we have compared gene expression profiles of a human CD4+ T cell line at 24 h after infection with a cell line of t...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-152
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:The use of sequence independent methods combined with next generation sequencing for identification purposes in clinical samples appears promising and exciting results have been achieved to understand unexplained infections. One sequence independent method, Virus Discovery based on cDNA Amplified Fragment Le...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-146
更新日期:2014-08-12 00:00:00
abstract:BACKGROUND:Aleutian mink disease virus (AMDV) is the cause of a chronic immune complex disease, Aleutian disease (AD), which is common in mink-producing countries. In 2005, implementation of an AMDV eradication programme in Finland created a need for an automated high-throughput assay. The aim of this study was to vali...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-141
更新日期:2014-08-08 00:00:00
abstract:BACKGROUND:Classical swine fever (CSF) is one of the most important viral diseases of pigs. Clinical signs may vary from almost inapparent infection to a hemorrhagic fever like illness. Among the host factors leading to different disease courses are age, breed, and immune status. The aim of this study was to compare ho...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-134
更新日期:2014-07-29 00:00:00
abstract::Virus taxonomy at present is best characterized as a categorization of convenience, without a firm basis in the principles of evolutionary biology. Specifically, virus species definitions appear to depend more on tradition and popular opinion among virologists than on firm, quantitative biological evidence. I suggest ...
journal_title:Virology journal
pub_type: 信件
doi:10.1186/1743-422X-11-131
更新日期:2014-07-23 00:00:00
abstract:BACKGROUND:Due to potential advantages, human adenoviral vectors have been evaluated pre-clinically as recombinant vaccine vectors against several cancers and infectious diseases, including human immunodeficiency virus (HIV) infection. The V3 loop of HIV-1 glycoprotein 120 (gp120) contains important neutralizing epitop...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-112
更新日期:2014-06-16 00:00:00
abstract:BACKGROUND:The family Mesoniviridae (order Nidovirales) comprises of a group of positive-sense, single-stranded RNA ([+]ssRNA) viruses isolated from mosquitoes. FINDINGS:Thirteen novel insect-specific virus isolates were obtained from mosquitoes collected in Indonesia, Thailand and the USA. By electron microscopy, the...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-97
更新日期:2014-05-20 00:00:00
abstract:BACKGROUND:Epstein-Barr virus (EBV) is associated with 20-40% of Hodgkin's Lymphoma (HL) cases. EBV-encoded latent membrane protein 1 (LMP1) is a well-known oncogenic protein and two C-terminal deletion variants, del30-LMP1 and del69-LMP1, have been described in animal models to be more tumorigenic than the wild-type f...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-94
更新日期:2014-05-19 00:00:00
abstract:BACKGROUND:Human Enterovirus 71 (EV71) has emerged as the leading cause of viral encephalitis in children, especially in the Asia-Pacific regions. EV71 vaccine development is of high priority at present, and neutralization antibodies have been documented to play critical roles during in vitro and in vivo protection aga...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-79
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Public health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recom...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-82
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Duck circovirus (DuCV) infection in farmed ducks is associated with growth problems or retardation syndromes. Rapid identification of DuCV infected ducks is essential to control DuCV effectively. Therefore, this study aims to develop of an assay for DuCV to be highly specific, sensitive, and simple without a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-76
更新日期:2014-04-29 00:00:00
abstract::Fatal influenza A virus infection is a major threat to public health throughout the world. Lung macrophages and neutrophils have critical roles for both the pathogenesis and viral clearance of fatal viral infections. These are complicated by the interaction of innate immunity and adaptive immunity against viral infect...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-57
更新日期:2014-03-26 00:00:00
abstract::Dengue virus (DENV) is a mosquito-borne virus that has four serotypes. Collection of serum from patients is time- and labor- consuming, and presents a high injury risk for infants and children. The genomic and serological diagnosis of imported dengue fever from a urine sample was used as a non-invasive diagnostic meth...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-56
更新日期:2014-03-25 00:00:00
abstract:BACKGROUND:Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and conjunctivitis, and approximately 80% of domestic cats are latently infected. Oral administration of...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-34
更新日期:2014-02-22 00:00:00
abstract:BACKGROUND:Ticks are implicated as hosts to a wide range of animal and human pathogens. The full range of microbes harbored by ticks has not yet been fully explored. METHODS:As part of a viral surveillance and discovery project in arthropods, we used unbiased high-throughput sequencing to examine viromes of ticks coll...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-26
更新日期:2014-02-11 00:00:00
abstract:BACKGROUND:Previously, we showed that the tetraspanin membrane protein CD63 mediates both early and post-integration stages of the HIV-1 replication cycle. The temporal roles of CD63 were discerned using monoclonal antibodies and small interfering RNAs (siRNAs) to block CD63 function, and determining which of the seque...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-23
更新日期:2014-02-08 00:00:00
abstract:BACKGROUND:Multi-resistant Achromobacter xylosoxidans has been recognized as an emerging pathogen causing nosocomially acquired infections during the last years. Phages as natural opponents could be an alternative to fight such infections. Bacteriophages against this opportunistic pathogen were isolated in a recent stu...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-14
更新日期:2014-01-27 00:00:00
abstract:BACKGROUND:Co-infection of multiple genotypes of human papillomavirus (HPV) is commonly observed among women with abnormal cervical cytology, but how different HPVs interact with each other in the same cell is not clearly understood. A previous study using cultured keratinocytes revealed that genome replication of one ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-11
更新日期:2014-01-24 00:00:00
abstract:BACKGROUND:Using a murine model of parainfluenza virus infection (mPIV1 or Sendai virus; SeV), we compared the inflammatory responses to lethal and sub-lethal infections in inbred DBA/2 mice. METHODS:Mice were intranasally inoculated with either 1.6×10(3) or 1.6×10(5) infectious units (IU) of SeV or diluent control. C...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-357
更新日期:2013-12-21 00:00:00
abstract:BACKGROUND:Mumps virus (MuV) is a highly infectious paramyxovirus closely related to measles virus (MeV). Despite the availability of a mumps vaccine, outbreaks continue to occur and no treatment options are available. Vitamin A and other naturally occurring retinoids inhibit the replication of MeV in vitro. METHODS:A...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-337
更新日期:2013-11-14 00:00:00
abstract:BACKGROUND:Newcastle Disease (ND) is a highly contagious and economically devastating disease of poultry. At present, limited molecular epidemiological data are available regarding the causes of ND outbreaks in vaccinated commercial poultry farms. Knowing the genomic characteristics of Newcastle disease virus (NDV) inf...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-330
更新日期:2013-11-09 00:00:00
abstract:BACKGROUND:West Nile virus (WNV) and Usutu virus (USUV), both belonging to the genus Flavivirus, are emerging in Italy as important human and animal pathogens. Migratory birds are involved in the spread of Flaviviruses over long distances, particularly from Africa to Europe. Once introduced, these viruses can be furthe...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-306
更新日期:2013-10-11 00:00:00
abstract:BACKGROUND:Acute gastroenteritis caused by bacteria, virus and parasite is an important cause of childhood morbidity and mortality in developing countries. Rotavirus and norovirus have been recognized as the most common pathogens causing acute gastroenteritis among children. However, there is still no valuable data abo...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-302
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:Progressive multifocal leukoencephalopathy (PML) onset, caused by Polyomavirus JC (JCPyV) in patients affected by immune-mediated diseases during biological treatment, raised concerns about the safety profile of these agents. Therefore, the aims of this study were the JCPyV reactivation monitoring and the no...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-298
更新日期:2013-09-30 00:00:00
abstract:BACKGROUND:Evaluation of the primary etiologic agents that cause aseptic meningitis outbreaks may provide valuable information regarding the prevention and management of aseptic meningitis. An outbreak of aseptic meningitis occurred from May to June, 2012, in Guangdong Province, China. In order to determine the etiolog...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-263
更新日期:2013-08-23 00:00:00
abstract:BACKGROUND:Due to the high prevalence of viral infections having no specific treatment and the constant appearance of resistant viral strains, the development of novel antiviral agents is essential. The aim of this study was to evaluate the antiviral activity against bovine viral diarrhea virus, herpes simplex virus ty...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-245
更新日期:2013-07-27 00:00:00
abstract:BACKGROUND:Nipah virus (NiV) is a zoonotic virus belonging to the henipavirus genus in the family Paramyxoviridae. Since NiV was first identified in 1999, outbreaks have continued to occur in humans in Bangladesh and India on an almost annual basis with case fatality rates reported between 40% and 100%. METHODS:Ferret...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-237
更新日期:2013-07-16 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences from Brazil were available, limiting the contribution of Brazilian isolates to the phylogenetic studies...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-236
更新日期:2013-07-16 00:00:00
abstract::Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal c...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-229
更新日期:2013-07-10 00:00:00
abstract:BACKGROUND:Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. FINDINGS:Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canoni...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-219
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Influenza viruses are characterized by their highly variable surface proteins HA and NA. The third surface protein M2 is a nearly invariant protein in all Influenza A strains. Despite extensive studies in other animal models, this study is the first to describe the use of recombinant M2 protein and a peptide...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-206
更新日期:2013-06-24 00:00:00
abstract:BACKGROUND:Few studies have used quantitative polymerase chain reaction (qPCR) as an approach to measure virus neutralization assay endpoints. Its lack of use may not be surprising considering that sample nucleic acid extraction and purification can be expensive, labor-intensive, and rate-limiting. METHODS:Virus/antib...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-195
更新日期:2013-06-15 00:00:00
abstract::Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strategies. Virus entry via endocytosis is a complex process involving hundreds of cellular proteins. The entire proc...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-10-177
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:Multiple studies proved that miRNAs have a causal role in tumorigenesis. Some miRNAs are regulated by epigenetic alterations in their promoter regions and can be activated by chromatin- modifying drugs. METHODS:We treated cervical cancer cells with 5-aza-2'-deoxycytidine and get a microarray analysis. Dysre...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-175
更新日期:2013-06-03 00:00:00
abstract:AIM:To evaluate the efficacy and safety of Entecavir (ETV) plus adefovir (ADV) for chronic hepatitis B (CHB) patients after multiple nucleos(t)ide analogue (NAs) failure treatment. METHODS:Hepatitis B e antigen (HBeAg)-positive patients who had a suboptimal response or developed resistance to two or more previous NAs ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-162
更新日期:2013-05-25 00:00:00
abstract:BACKGROUND:The genetic element s2m seems to represent one of very few examples of mobile genetic elements in viruses. The function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. METHODS:We have searched GenBank in order to identify all viral accessions that have s2m(-lik...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-132
更新日期:2013-04-25 00:00:00
abstract:BACKGROUND:Otitis media (OM) affects ≥80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/3...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-128
更新日期:2013-04-23 00:00:00
abstract:BACKGROUND:During October 2010, Egypt reported an outbreak of acute hemorrhagic conjunctivitis (AHC). A total of 1831 cases were reported from three governorates; 1703 cases in El Daqahliya, 92 cases in Port Said, and 36 in Damietta. The purpose of this study was to identify and characterize the causative agent associa...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-96
更新日期:2013-03-25 00:00:00
abstract:BACKGROUND:The context and purpose of the study included 1) bacterial expression of viral protein 6 (VP6) of porcine rotavirus (PRV) and generation of rabbit polyclonal antiserum to the VP6 protein; 3) establishment of a discrimination ELISA to distinguish PRV from a panel of other porcine viruses. RESULTS:The VP6 gen...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-91
更新日期:2013-03-22 00:00:00